2013 U HDHB:05-11-26 HDHB:05-11-26 08:59:41.000 HDHB:05-11-26 utf8 0 Osu Text txt Computermedien c Online-Ressource cr 1988388694 10.1002/ejp.70287 KXP 1988388694 eng rda 2026 May 2026 https://doi.org/10.1002/ejp.70287 H R Volltext LF 34 https://onlinelibrary.wiley.com/doi/abs/10.1002/ejp.70287 H Volltext LF 34 Conditioned pain modulation inter-site variability study effect sizes and test-retest reliability of two models Yi-Wun Lin, Hannah Schmidt, Niko Möller-Grell, Walter Magerl, Li-Ling Hope Pan, Shuu-Jiun Wang, Li-Wei Chou, Rolf-Detlef Treede 1988390907 Tpv3 gnd/1423875532 piz Lin Yi-Wun 1996 VerfasserIn aut 1932511954 Tpv3 gnd/1373186224 piz Schmidt Hannah 1993 VerfasserIn aut 1945081171 Tpv3 gnd/1383819432 piz Möller-Grell Niko 1996 VerfasserIn aut 730453138 Tpv3 gnd/1028214235 37571247X piz Magerl Walter VerfasserIn aut Li-Ling Hope Pan VerfasserIn aut Shuu-Jiun Wang VerfasserIn aut Li-Wei Chou VerfasserIn aut 606699856 Tpv1 gnd/109865960 309492459 piz Treede Rolf-Detlef 1956 VerfasserIn aut 30 2026 5 5 e70287 1-14 14 Diagramme Erstmals veröffentlicht: 4. Mai 2026 Gesehen am 05.11.2026 Enthalten in 320420485 Obv zdb/2002493-9 267761791 1532-2149 European journal of pain Malden, Mass. [u.a.] Wiley-Blackwell 1997 Online-Ressource 202600000300005999 s conditioned pain modulation s heat pain sensitivity s pressure pain threshold s reference data s test-retest reliability Alle Personen wegen Universitätsbibliographie Heidelberg bitte stehen lassen! HDHB/05.11.2026 Background Conditioned pain modulation (CPM) is a set of psychophysical paradigms that is increasingly used clinically to evaluate descending pain modulation pathways. Impairment is common in chronic pain, suggesting CPM may serve as a mechanistic indicator. However, the lack of protocol standardization and reference data prevents clinical use in individual patients. Methods We compared two CPM protocols with different conditioning stimulus intensities, test stimulus types, and interaction timing. We assessed CPM effect size, test-retest reliability and sensitivity to detect loss of descending inhibition. Results Conditioning with 0°C water led to stronger inhibition of pressure pain threshold (PPT) than conditioning with 7°C water (Cohen's d = 0.52), when tested immediately after conditioning. When tested during conditioning, effects of 7°C water immersion on heat pain sensitivity had similar magnitude (D = 0.53) and test-retest reliability (ICC = 0.77) as those on PPT (D = 0.54, ICC = 0.73). For all outcomes assessed, 95% confidence intervals (CI) of CPM effect included some facilitation instead of inhibition. The maximum degree of facilitation compatible with normal CPM (upper cutoff of CI) indicates potential sensitivity to detect individual abnormality. This was most favourable for PPT assessed after conditioning with 0°C water (decrease by more than 75 kPa or 14% of baseline PPT). Conclusions In conclusion, testing during conditioning stimulation yields medium to large effect sizes and good test-retest reliability. PPT testing immediately after ice water immersion has the narrowest 95% CI and hence offers the potential to generalize CPM assessments beyond group-level differences and compare inhibition among individuals in clinical practice. Significance Statement Indicating the main aspects where this work adds significantly to existing knowledge in the field, and if appropriate to clinical practice. Simultaneous CPM protocols exhibit large effect sizes but are confounded by divided attention. We recommend a sequential protocol and provide model reference data for abnormal facilitation. 2013 BSZ 05-11-26 05-11-26 10:18:04.000 HDHB:05-11-26 utf8 5062268311 05-11-26 l01 16/250 00 fl 14 s hd2026 00 s 1410508463 Tdi 340508469 wissenschaftlicher Artikel (Zeitschrift) 01 s per_8 02 s s_14 03 p 198839094X Tdi Lin Yi-Wun 04 k 1416822720 Tdi 346822726 Extern 04 s 1410501914 Tdi 34050191X Verfasser 04 s pos_1 04 p 1932511946 Tdi Schmidt Hannah 05 k 1693597993 Tdi Mannheim Center for Translational Neuroscience (MCTN) 05 k 1416467254 Tdi 34646725X Medizinische Fakultät Mannheim 05 s 1410501914 Tdi 34050191X Verfasser 05 s pos_2 05 p 1945081198 Tdi Möller-Grell Niko 06 k 1416467254 Tdi 34646725X Medizinische Fakultät Mannheim 06 k 1416466967 Tdi 346466962 Medizinische Fakultät Heidelberg 06 s 1410501914 Tdi 34050191X Verfasser 06 s pos_3 06 p 1445712970 Tdi 375712976 Magerl Walter 07 k 1693597993 Tdi Mannheim Center for Translational Neuroscience (MCTN) 07 s 1410501914 Tdi 34050191X Verfasser 07 s pos_4 07 p 1445312557 Tdi 375312552 Treede Rolf-Detlef 08 k 1416467254 Tdi 34646725X Medizinische Fakultät Mannheim 08 s 1410501914 Tdi 34050191X Verfasser 08 s pos_8 08 11