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The 105 full papers included in these volumes were carefully reviewed and selected from 415 submissions. They are organized into thematic sections as follows: Emerging Devices and Technology; Analog and Mixed Signal Design; Digital Design and Systems; Memory and Computing Architectures; RF and Embedded Systems; AI Accelerators and Advanced Architectures. .</abstract><note type="statement of responsibility">edited by Brajesh Rawat, Hitesh Shirmali, Shivani Malhotra, Rohit Y. Sharma, Neeraj Goel</note><note>Print version record</note><note>PDF/UA-1. Table of contents navigation. Single logical reading order. Short alternative textual descriptions. Use of colour is Not sole means of conveying information. Use of high contrast between text and background colour. Next / Previous structural navigation. All Non-decorative content supports reading without sight</note><note>Accessibility summary: This PDF has been created in accordance with the PDF/UA-1 standard to enhance accessibility. 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<srw:recordPosition>9</srw:recordPosition><srw:recordData><mods xmlns="http://www.loc.gov/mods/v3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" version="3.5" xsi:schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-5.xsd"><titleInfo><title>Zytometrische Detektion des GPA33-Antigens in Blut-Monozyten, ein neuer Test zur Spezifizierung der Frühdetektion des kolorektalen Karzinoms</title></titleInfo><name type="personal" authority="gnd" authorityURI="http://d-nb.info/gnd/" valueURI="http://d-nb.info/gnd/1423986075"><displayForm>Gemeinhardt, Cynthia</displayForm><namePart type="given">Cynthia</namePart><namePart type="family">Gemeinhardt</namePart><namePart type="date">1996</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><name type="personal" authority="gnd" authorityURI="http://d-nb.info/gnd/" valueURI="http://d-nb.info/gnd/1237077095"><displayForm>Friedrich, Karl-Heinz</displayForm><namePart type="given">Karl-Heinz</namePart><namePart type="family">Friedrich</namePart><namePart type="date">1957</namePart><role><roleTerm type="code" authority="marcrelator">dgs</roleTerm><roleTerm type="text">AkademischeR BetreuerIn</roleTerm></role></name><name type="personal" authority="gnd" authorityURI="http://d-nb.info/gnd/" valueURI="http://d-nb.info/gnd/120207141"><displayForm>Rubio, Ignacio</displayForm><namePart type="given">Ignacio</namePart><namePart type="family">Rubio</namePart><namePart type="date">1968</namePart><role><roleTerm type="code" authority="marcrelator">dgs</roleTerm><roleTerm type="text">AkademischeR BetreuerIn</roleTerm></role></name><name type="personal" authority="gnd" authorityURI="http://d-nb.info/gnd/" valueURI="http://d-nb.info/gnd/123300924"><displayForm>Weßler, Silja</displayForm><namePart type="given">Silja</namePart><namePart type="family">Weßler</namePart><namePart type="date">1970</namePart><role><roleTerm type="code" authority="marcrelator">dgs</roleTerm><roleTerm type="text">AkademischeR BetreuerIn</roleTerm></role></name><name type="corporate" authority="gnd" authorityURI="http://d-nb.info/gnd/" valueURI="http://d-nb.info/gnd/36164-1"><namePart>Friedrich-Schiller-Universität Jena</namePart><role><roleTerm type="code" authority="marcrelator">dgg</roleTerm><roleTerm type="text">Grad-verleihende Institution</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="gnd" authorityURI="http://d-nb.info/gnd/" valueURI="http://d-nb.info/gnd/4113937-9">Hochschulschrift</genre><originInfo eventType="publication"><place><placeTerm type="text">Zwickau</placeTerm></place><dateIssued encoding="w3cdtf" keyDate="yes">2026</dateIssued><dateIssued>23.02.2026</dateIssued><issuance>monographic</issuance></originInfo><language><languageTerm authority="iso639-2b" type="code">ger</languageTerm></language><physicalDescription><extent>1 Online-Ressource (92 Seiten)</extent><note>Illustrationen, Diagramme</note></physicalDescription><abstract type="scope">Das Kolorektale Karzinom ist eine der häufigsten krebsbedingten Todesursachen in Deutschland. Als neuen Ansatz zur Krebs-Früherkennung wird EDIM (Epitope Detection in Monocytes) verfolgt. Dabei werden die Tumormarker Apo10 und TKTL1 in CD14+/CD16+-Monozyten im Blut zytometrisch detektiert. Der Test kann mit hoher Sensitivität und Spezifität Karzinome erkennen, lässt jedoch keine Aussage zur Karzinomlokalisation zu. Eine Lösung dafür soll die Kombination mit dem spezifisch in Darmepithelzellen exprimierten Membranprotein GPA33 darstellen. In dieser Arbeit wurden monoklonale Antikörper gegen GPA33 hinsichtlich ihrer Eignung für den Einsatz im EDIM-Verfahren charakterisiert. Dafür wurden die Antikörper zytometrisch an GPA33 exprimierenden (HT-29) und nicht-exprimierenden (HEK293T) Zellen getestet. Dabei zeigte ein großer Teil der Antikörper eine sensitive und spezifische Bindung gegenüber GPA33. Weiterhin wurden Modellversuche mit GPA33 transfizierten monozytären Zellen (THP-1 und U937) durchgeführt, um zu überprüfen, ob sich das GPA33 Antigen auch in Monozyten detektieren lässt. Außerdem wurde versucht, bakteriell exprimiertes GPA33 nach Phagozytose transformierter E. coli Bakterien durch differenzierte U937-Zellen nachzuweisen. Die genutzten Antikörper waren auch nach Optimierungsversuchen nicht in der Lage, GPA33 in monozytären Zelllinien zu erkennen. Parallel wurden PE-konjugierte GPA33-Antikörper an menschlichen Blutproben anhand des EDIM-Protokolls getestet. Ebenfalls wurden Färbungen gegen die allgemeinen Tumormarker Apo10 und TKTL1 durchgeführt. In der statistischen Auswertung zeigte sich, dass fünf der sechs genutzten GPA33-Antikörper signifikant zwischen Proben der Gruppen „CRC“ und „kein CRC“ unterscheiden konnten. Obwohl weiterführende Tests und Optimierungen der Analysebedingungen nötig sind, stellen die Ergebnisse zusammenfassend einen vielversprechenden Beitrag für die perspektivische Entwicklung eines neuen Tests zum Darmkrebs-Screening dar.</abstract><note type="thesis statement">Friedrich-Schiller-Universität Jena, Dissertation, 2026</note><note type="statement of responsibility">von Charlotte Cynthia Gemeinhardt</note><note>Tag der Verteidigung: 05.10.2026</note><subject><topic authority="gnd" authorityURI="http://d-nb.info/gnd/" valueURI="http://d-nb.info/gnd/4012122-7">Dickdarmkrebs</topic></subject><subject><topic authority="gnd" authorityURI="http://d-nb.info/gnd/" valueURI="http://d-nb.info/gnd/4071905-4">Glykoproteine</topic></subject><subject authority="gnd" authorityURI="http://d-nb.info/gnd/" valueURI="http://d-nb.info/gnd/4028557-1"><geographic>Jena</geographic></subject><identifier type="urn">urn:nbn:de:gbv:27-dbt-72440-6</identifier><identifier type="kxp">1988473195</identifier><location><url displayLabel="Langzeitarchivierung" note="Kostenfrei zugänglich ohne Registrierung">https://doi.org/10.22032/dbt.72440</url></location><extension><vlz:externalType xmlns:vlz="http://visuallibrary.net/vlz/1.0/" recordSyntax="pica" code="Oa"/><vlz:info xmlns:vlz="http://visuallibrary.net/vlz/1.0/" version="0"/></extension><recordInfo><recordCreationDate encoding="marc">06-11-26</recordCreationDate><recordChangeDate encoding="marc">06-11-26</recordChangeDate><recordIdentifier source="gbv-sru">1988473195</recordIdentifier><descriptionStandard>rda</descriptionStandard></recordInfo></mods></srw:recordData></srw:record><srw:record>
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<srw:recordPosition>10</srw:recordPosition><srw:recordData><mods xmlns="http://www.loc.gov/mods/v3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" version="3.5" xsi:schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-5.xsd"><titleInfo><title>Zytometrische Detektion des GPA33-Antigens in Blut-Monozyten, ein neuer Test zur Spezifizierung der Frühdetektion des kolorektalen Karzinoms</title></titleInfo><name type="personal" authority="gnd" authorityURI="http://d-nb.info/gnd/" valueURI="http://d-nb.info/gnd/1423986075"><displayForm>Gemeinhardt, Cynthia</displayForm><namePart type="given">Cynthia</namePart><namePart type="family">Gemeinhardt</namePart><namePart type="date">1996</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><name type="personal" authority="gnd" authorityURI="http://d-nb.info/gnd/" valueURI="http://d-nb.info/gnd/1237077095"><displayForm>Friedrich, Karl-Heinz</displayForm><namePart type="given">Karl-Heinz</namePart><namePart type="family">Friedrich</namePart><namePart type="date">1957</namePart><role><roleTerm type="code" authority="marcrelator">dgs</roleTerm><roleTerm type="text">AkademischeR BetreuerIn</roleTerm></role></name><name type="personal" authority="gnd" authorityURI="http://d-nb.info/gnd/" valueURI="http://d-nb.info/gnd/120207141"><displayForm>Rubio, Ignacio</displayForm><namePart type="given">Ignacio</namePart><namePart type="family">Rubio</namePart><namePart type="date">1968</namePart><role><roleTerm type="code" authority="marcrelator">dgs</roleTerm><roleTerm type="text">AkademischeR BetreuerIn</roleTerm></role></name><name type="personal" authority="gnd" authorityURI="http://d-nb.info/gnd/" valueURI="http://d-nb.info/gnd/123300924"><displayForm>Weßler, Silja</displayForm><namePart type="given">Silja</namePart><namePart type="family">Weßler</namePart><namePart type="date">1970</namePart><role><roleTerm type="code" authority="marcrelator">dgs</roleTerm><roleTerm type="text">AkademischeR BetreuerIn</roleTerm></role></name><name type="corporate" authority="gnd" authorityURI="http://d-nb.info/gnd/" valueURI="http://d-nb.info/gnd/36164-1"><namePart>Friedrich-Schiller-Universität Jena</namePart><role><roleTerm type="code" authority="marcrelator">dgg</roleTerm><roleTerm type="text">Grad-verleihende Institution</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="gnd" authorityURI="http://d-nb.info/gnd/" valueURI="http://d-nb.info/gnd/4113937-9">Hochschulschrift</genre><originInfo eventType="publication"><place><placeTerm type="text">Zwickau</placeTerm></place><dateIssued encoding="w3cdtf" keyDate="yes">2026</dateIssued><dateIssued>23.02.2026</dateIssued><issuance>monographic</issuance></originInfo><language><languageTerm authority="iso639-2b" type="code">ger</languageTerm></language><physicalDescription><extent>VIII, 84 Seiten ; 30 cm</extent><note>Illustrationen, Diagramme</note></physicalDescription><abstract type="scope">Das Kolorektale Karzinom ist eine der häufigsten krebsbedingten Todesursachen in Deutschland. Als neuen Ansatz zur Krebs-Früherkennung wird EDIM (Epitope Detection in Monocytes) verfolgt. Dabei werden die Tumormarker Apo10 und TKTL1 in CD14+/CD16+-Monozyten im Blut zytometrisch detektiert. Der Test kann mit hoher Sensitivität und Spezifität Karzinome erkennen, lässt jedoch keine Aussage zur Karzinomlokalisation zu. Eine Lösung dafür soll die Kombination mit dem spezifisch in Darmepithelzellen exprimierten Membranprotein GPA33 darstellen. In dieser Arbeit wurden monoklonale Antikörper gegen GPA33 hinsichtlich ihrer Eignung für den Einsatz im EDIM-Verfahren charakterisiert. Dafür wurden die Antikörper zytometrisch an GPA33 exprimierenden (HT-29) und nicht-exprimierenden (HEK293T) Zellen getestet. Dabei zeigte ein großer Teil der Antikörper eine sensitive und spezifische Bindung gegenüber GPA33. Weiterhin wurden Modellversuche mit GPA33 transfizierten monozytären Zellen (THP-1 und U937) durchgeführt, um zu überprüfen, ob sich das GPA33 Antigen auch in Monozyten detektieren lässt. Außerdem wurde versucht, bakteriell exprimiertes GPA33 nach Phagozytose transformierter E. coli Bakterien durch differenzierte U937-Zellen nachzuweisen. Die genutzten Antikörper waren auch nach Optimierungsversuchen nicht in der Lage, GPA33 in monozytären Zelllinien zu erkennen. Parallel wurden PE-konjugierte GPA33-Antikörper an menschlichen Blutproben anhand des EDIM-Protokolls getestet. Ebenfalls wurden Färbungen gegen die allgemeinen Tumormarker Apo10 und TKTL1 durchgeführt. In der statistischen Auswertung zeigte sich, dass fünf der sechs genutzten GPA33-Antikörper signifikant zwischen Proben der Gruppen „CRC“ und „kein CRC“ unterscheiden konnten. 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