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<srw:recordPosition>8</srw:recordPosition><srw:recordData><mods xmlns="http://www.loc.gov/mods/v3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" version="3.5" xsi:schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-5.xsd"><titleInfo><title>Variation in diagnostic performance of fecal immunochemical test (FIT) by cutoffs used in screening programs globally</title></titleInfo><name type="personal" authority="gnd" authorityURI="http://d-nb.info/gnd/" valueURI="http://d-nb.info/gnd/1352849062"><displayForm>Ola, Idris</displayForm><namePart type="given">Idris</namePart><namePart type="family">Ola</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><name type="personal" authority="gnd" authorityURI="http://d-nb.info/gnd/" valueURI="http://d-nb.info/gnd/1357938993"><displayForm>Seum, Teresa</displayForm><namePart type="given">Teresa</namePart><namePart type="family">Seum</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><name type="personal"><displayForm>Carlsson, Sigrid V.</displayForm><namePart type="given">Sigrid V.</namePart><namePart type="family">Carlsson</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><name type="personal" authority="gnd" authorityURI="http://d-nb.info/gnd/" valueURI="http://d-nb.info/gnd/134103726"><displayForm>Hoffmeister, Michael</displayForm><namePart type="given">Michael</namePart><namePart type="family">Hoffmeister</namePart><namePart type="date">1973</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><name type="personal" authority="gnd" authorityURI="http://d-nb.info/gnd/" valueURI="http://d-nb.info/gnd/1020516445"><displayForm>Brenner, Hermann</displayForm><namePart type="given">Hermann</namePart><namePart type="family">Brenner</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><typeOfResource>text</typeOfResource><originInfo><dateIssued encoding="w3cdtf" keyDate="yes">2026</dateIssued><dateIssued>April 2026</dateIssued></originInfo><language><languageTerm authority="iso639-2b" type="code">eng</languageTerm></language><physicalDescription><note>Diagramme</note></physicalDescription><abstract type="scope">Background - Quantitative fecal immunochemical test (FIT) is widely used for colorectal cancer (CRC) screening, with substantial variation in positivity thresholds across countries. This study examines how these thresholds affect FIT's diagnostic performance for detecting CRC and advanced precancerous lesions (APCL). - Methods - We analyzed data from a single round screening of 7398 men and women aged 50-79 years, enrolled between 2008 and 2020 in the German BLITZ study, who provided a stool sample for FIT prior to screening colonoscopy. Using FIT positivity thresholds from 30 countries across five continents, we estimated positivity rates, sensitivities for CRC, APCL, and any advanced neoplasia (AN), as well as specificity for no AN, with colonoscopy as the reference standard. Subgroup analyses were conducted by age and sex. - Findings - FIT positivity thresholds across the included countries ranged from 8.5 (Belgium, Flanders) to 120 μg Hb/g feces (England, Wales and Northern Ireland). This wide range went along with very wide ranges of positivity rates and diagnostic performance parameters: positivity rate, 17.6% (95% CI: 16.7-18.5) to 2.6% (95% CI: 2.3-3.0); sensitivity for CRC, 98.1% (95% CI: 90.1-100.0) to 55.6% (41.4-69.1); sensitivity for APCL, 45.5% (95% CI: 41.9-49.0) to 12.2% (95% CI: 10.0-14.7); sensitivity for any AN, 48.9% (95% CI: 45.4-52.4) to 15.0% (95% CI: 12.7-17.7); specificity for no AN, 86.3% (95% CI: 85.5-87.2) to 98.9% (95% CI: 98.7-99.2). - Interpretation - The broad range of FIT positivity thresholds across countries goes along with very different diagnostic performance parameters. While this limits comparability of results between countries, our results underscore the potential of FIT as a flexible screening tool that can be adapted to the evolving healthcare system capacities in different countries. - Funding - German Research Council, the Federal Ministry of Education and Research, and the German Cancer Aid.</abstract><note type="statement of responsibility">Idris Ola, Teresa Seum, Sigrid V. Carlsson, Michael Hoffmeister, and Hermann Brenner</note><note>Online verfügbar: 16. März 2026</note><note>Gesehen am 16.06.2026</note><subject><topic>Colonoscopy</topic></subject><subject><topic>Colorectal cancer screening</topic></subject><subject><topic>FIT thresholds</topic></subject><subject><topic>Sensitivity</topic></subject><subject><topic>Specificity</topic></subject><subject><topic>Stool-based test</topic></subject><relatedItem type="host"><titleInfo><title>EClinicalMedicine</title></titleInfo><originInfo><place><placeTerm>Amsterdam</placeTerm></place><publisher>Elsevier</publisher><dateIssued>2018</dateIssued></originInfo><physicalDescription><note>Online-Ressource</note></physicalDescription><recordInfo><recordIdentifier source="gbv-sru-suubcasual">1035271834</recordIdentifier></recordInfo></relatedItem><identifier type="kxp">1973102285</identifier><location><url displayLabel="Resolving-System" note="Kostenfrei zugänglich ohne Registrierung">https://doi.org/10.1016/j.eclinm.2026.103835</url></location><location><url displayLabel="Verlag" note="Kostenfrei zugänglich ohne Registrierung">https://www.sciencedirect.com/science/article/pii/S2589537026000829</url></location><part order="94"><detail type="volume"><number>94</number></detail><extent unit="page"><start>1</start><end>9</end></extent></part><extension><vlz:externalType xmlns:vlz="http://visuallibrary.net/vlz/1.0/" recordSyntax="pica" code="Os"/><vlz:info xmlns:vlz="http://visuallibrary.net/vlz/1.0/" version="0"/></extension><recordInfo><recordCreationDate encoding="marc">16-06-26</recordCreationDate><recordChangeDate encoding="marc">16-06-26</recordChangeDate><recordIdentifier source="gbv-sru-suubcasual">1973102285</recordIdentifier><descriptionStandard>rda</descriptionStandard></recordInfo></mods></srw:recordData></srw:record><srw:record>
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<srw:recordPosition>9</srw:recordPosition><srw:recordData><mods xmlns="http://www.loc.gov/mods/v3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" version="3.5" xsi:schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-5.xsd"><titleInfo><title>The God Test</title></titleInfo><name type="personal"><displayForm>Wright, Robert</displayForm><namePart type="given">Robert</namePart><namePart type="family">Wright</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><typeOfResource>text</typeOfResource><originInfo eventType="publication"><place><placeTerm type="text">Riverside</placeTerm></place><publisher>Simon &amp; Schuster</publisher><dateIssued encoding="w3cdtf" keyDate="yes">2026</dateIssued><edition>Export ed</edition><issuance>monographic</issuance></originInfo><language><languageTerm authority="iso639-2b" type="code">eng</languageTerm></language><physicalDescription><extent>354 Seiten</extent></physicalDescription><abstract type="scope">From bestselling author and Pulitzer Prize finalist Robert Wright comes a sweeping new view of artificial intelligence-as an evolutionary force that will pose deep political and spiritual challenges and could, in the process, give our species a unifying sense of purpose.  The God Test is the first book to capture the power behind the AI revolution-to clearly explain the breakthroughs that sparked the current wave of advance and compellingly show why this wave will grow in magnitude and meaning. Written by one of our foremost public intellectuals, and informed by his decades of chronicling the digital age, the book argues that we are about to witness the most abruptly dramatic social transformation in the history of our species.  Wright says that to truly understand this moment in technological history, we need to expand our perspective beyond the last century or even the whole history of technology and look back across billions of years of life on Earth. The advance of AI, he argues, is driven by evolutionary dynamics like those that led to intelligent life in the first place. And understanding those dynamics can empower us to confront our climactic challenge: Can we muster the political, moral, and even spiritual resources needed to guide this technology wisely?  If we fail, the consequences for the whole planet could be grave. But if we meet the challenge-if we pass "the God test"-we can live in a world where humanity thrives, finding not just happiness but deeper meaning and purpose. The very machines that might otherwise imperil or oppress us can enrich us, helping us transcend the psychological impediments to human concord and fulfillment</abstract><note type="statement of responsibility">Robert Wright</note><subject><topic>COMPUTERS / Expert Systems</topic></subject><subject><topic>Expert systems / knowledge-based systems</topic></subject><subject><topic>Prognosen, Zukunftsstudien</topic></subject><subject><topic>SOCIAL SCIENCE / Future Studies</topic></subject><subject><topic>Social forecasting, future studies</topic></subject><subject><topic>Wissensbasierte Systeme, Expertensysteme</topic></subject><identifier type="kxp">1973093839</identifier><extension><vlz:externalType xmlns:vlz="http://visuallibrary.net/vlz/1.0/" recordSyntax="pica" code="Aa"/><vlz:info xmlns:vlz="http://visuallibrary.net/vlz/1.0/" version="0"/></extension><recordInfo><recordCreationDate encoding="marc">15-06-26</recordCreationDate><recordChangeDate encoding="marc">15-06-26</recordChangeDate><recordIdentifier source="gbv-sru-suubcasual">1973093839</recordIdentifier><descriptionStandard>rda</descriptionStandard></recordInfo></mods></srw:recordData></srw:record><srw:record>
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<srw:recordPosition>10</srw:recordPosition><srw:recordData><mods xmlns="http://www.loc.gov/mods/v3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" version="3.5" xsi:schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-5.xsd"><titleInfo><title>Getting in Is Not Enough</title><subTitle>The New Blueprint for Success Beyond Grades, Test Scores, and College Admission</subTitle></titleInfo><name type="personal"><displayForm>Homayoun, Ana</displayForm><namePart type="given">Ana</namePart><namePart type="family">Homayoun</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><typeOfResource>text</typeOfResource><originInfo eventType="publication"><place><placeTerm type="text">[Erscheinungsort nicht ermittelbar]</placeTerm></place><publisher>Balance</publisher><dateIssued encoding="w3cdtf" keyDate="yes">2026</dateIssued><issuance>monographic</issuance></originInfo><language><languageTerm authority="iso639-2b" type="code">eng</languageTerm></language><physicalDescription><extent>256 Seiten</extent></physicalDescription><note type="statement of responsibility">Ana Homayoun</note><subject><topic>Advice on parenting</topic></subject><subject><topic>Age groups: children</topic></subject><subject><topic>Altersgruppen: Kinder</topic></subject><subject><topic>Child &amp; developmental psychology</topic></subject><subject><topic>EDU051000</topic></subject><subject><topic>EDU060010</topic></subject><subject><topic>EDUCATION / History</topic></subject><subject><topic>Educational psychology</topic></subject><subject><topic>Entwicklungspsychologie</topic></subject><subject><topic>FAMILY &amp; RELATIONSHIPS / Parenting / General</topic></subject><subject><topic>Geschichte der Pädagogik</topic></subject><subject><topic>History of education</topic></subject><subject><topic>PSYCHOLOGY / Developmental / Child</topic></subject><subject><topic>Pädagogische Psychologie</topic></subject><subject><topic>Ratgeber für Eltern</topic></subject><subject><topic>Schools</topic></subject><subject><topic>Schulen und Vorschulen</topic></subject><classification authority="ddc">370.973</classification><identifier type="kxp">1973093081</identifier><extension><vlz:externalType xmlns:vlz="http://visuallibrary.net/vlz/1.0/" recordSyntax="pica" code="Aa"/><vlz:info xmlns:vlz="http://visuallibrary.net/vlz/1.0/" version="0"/></extension><recordInfo><recordCreationDate encoding="marc">15-06-26</recordCreationDate><recordChangeDate encoding="marc">15-06-26</recordChangeDate><recordIdentifier source="gbv-sru-suubcasual">1973093081</recordIdentifier><descriptionStandard>rda</descriptionStandard></recordInfo></mods></srw:recordData></srw:record></srw:records>
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